The French president is embarking on a three-day trip of western Africa aimed at boosting France's regional influence, stemming the continent's migrant exodus and bolstering the fight against violent Islamist militancy in the Sahel.
The visit was marred by an attempted attack on French troops in the capital Ouagadougou just hours before Macron's arrival.
“Two hooded individuals on a motorcycle threw a grenade towards a French army vehicle” as it made its way to a barracks housing French special forces, a security source told AFP on condition of anonymity.
Three residents were wounded, one seriously, in the attack which took place at 8:00 pm (2000 GMT), the source added.
“The attackers' target was the French army vehicle, which was not hit,” the source said.
An AFP reporter at the scene of the attack witnessed a small hole in the tarmac where the grenade detonated and a damaged civilian vehicle.
Macron flew into Ouagadougou three hours later for a trip that will take in Burkina Faso and Ivory Coast — two former French colonies that deposed strongmen leaders in recent years — as well as to Ghana.
His advisors say his primary message will be to stress a partnership of equals with Africa, based on education and entrepreneurship.
But regional security concerns will also dominate.
European leaders are desperate to find ways to stem the flow of African migrants across the Mediterranean without leaving them to the mercy of
traffickers in transit countries like Libya, where they face torture, rape, and — as a CNN report showed recently — being sold into slavery.
And Macron will also be seeking international backing for a new, five-nation African counter-terrorism force, which France hopes to see
eventually take over the fight against jihadist groups in the Sahel region.
Ouagadougou has suffered two recent terror attacks carried out by Islamist militants — a shooting spree in January 2016 that left 20 dead and a similar
assault by gunmen in August that killed 19.