Météo France, the country's meteorological service has issued orange alert warnings – the second highest grade of alert – for eight departments.
These are Aube, Marne, Haute-Marne, Meurthe-et-Moselle, Meuse, Moselle, Seine-et-Marne and Bas-Rhin.
Heavy rain and storms are set to hit the area Wednesday at around 6pm, which could lead to flooding.
The national weather agency predicts that the rain will "intensify" during the evening, "becoming moderate to strong during Wednesday night for the areas on orange alert".
Map: Météo France
The alerts are set to stay in place until Thursday, 6am.
The Orange alert asks residents to be vigilant especially when travelling.