Macron's visit to the islands of St Martin and St Barts comes almost a week since Hurricane Irma roared over the region as a maximum Category Five storm, leaving at least 10 dead on French territory and a wide trail of destruction.
Authorities have begun evacuating locals and tourists from the hardest-hit French, British and Dutch territories in the Caribbean where many have complained about a breakdown in law and order and widespread shortages of food, water and electricity.
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"Even from the plane I saw something I have never seen before," the Dutch royal told the NOS public newscaster. "I have seen proper war as well as natural disasters before, but I've never seen anything like this".
"Everywhere you look there's devastation, you see the collapse," he added.
Like the French and Dutch governments, Britain has also faced criticism for failing to anticipate the scale of the disaster caused by Irma.
Under pressure to be more responsive, foreign minister Boris Johnson is expected to travel to the region on Tuesday for a visit to the British Virgin Islands and Anguilla.
According to the latest official figures, Irma left 10 people dead and seven missing on the French islands, four dead on Dutch territories and six dead on British ones.
Macron's plane touched down in Guadeloupe Tuesday enroute to St Martin.
"He needs to come to look around, so that he realises the horror here," one local on St Martin, Peggy Brun, told AFP.