"At 37.6 million hectolitres (993.3 million gallons) the 2017 harvest is set to come in 17 percent lower than in 2016 and 16 percent below the average of the past five years," the ministry's statistics bureau Agreste said on Saturday.
As such, the traditional August to October harvest of the second largest global producer will come in "historically low and below that of 1991, which was also hit by severe frost."
The cold wrought havoc notably in the South West, with Bordeaux suffering along with neighbouring Charente but also Alsace in the northeast and between the Burgundy region and Switzerland.
Even the deep south did not escape, with the Languedoc region also affected.
The Mediterranean region was hit by a problem of a different variety as wind and rain caused the phenomenon of "coulure" where grapes, most notably the grenache variety, fail to develop properly after vines have flowered.