The incident happened on Sunday afternoon at the French Alps resort of Flaine, in the Haute-Savoie part of the Alps.
The 43-year-old was skiing down the blue run, a fairly easy slope suitable for beginners and intermediate-level skiers, when he crashed into another skier.
Two doctors who witnessed the crash raised the alarm and tried gave initial treatment to the two skiers, before being helped by the paramedics and specialist mountain police.
However, the 43-year-old died as a result of his injuries. It was not clear whether he was wearing a helmet.
The second skier, the sex and age of whom is not yet known, survived the crash but was left with injuries. Their exact condition is also unknown.
Police have opened an investigation.
It has been a winter marred by a series of fatal incidents in the Alps, some caused by avalanches and others by crashes.
In February, The Local reported how a teenager died after sledding down a piste on a mattress normally used as a safety barrier.
He was one of five who hauled the mattress up the slope after a night drinking. But as they slid back down, they lost control and it hurtled into trees.
The crash at Les Deux Alpes came in the same week a British skier died after she lost control on beginners slope and hit a tree at La Plagne resort.