Three men and one woman were arrested on Monday for involvement in repeat attacks, a police source told the Direct Matin newspaper
All the aggressors are in their twenties and originally from Calais, reported La Voix du Nord.
The arrests follow an in-depth investigation by police after summer saw a spate of attacks on the camp's migrants.
A prosecutor said there were two gangs of attackers who were responsible for “at least a dozen assaults”.
According to reports they beat up four migrants who were waiting by the road to try to board trucks bound for the UK.
There have been numerous reports of migrants in the Calais region being attacked in recent months.
According to Medecins du Monde, a charity working in the area to improve conditions for migrants, the number of attacks has risen since the beginning of the year.
“Tens of people have been beaten up with iron bars in Calais, leaving them with multiple fractures,” one worker said.
“Around 500 to 1,000 migrants will just disappear because there is nowhere for them to go,” Michel Janssens from the charity Medecins sans Frontieres told The Local.
“It's not human to do that. We are not fighting for them to keep the camp but for the occupants to be given adequate and humane lodging,” Janssens added.
“All this will do is see hundreds end up living in clandestine camps.”