French police staged 128 raids in the early hours of Tuesday, Interior Minister Bernard Cazeneuve said.
The raids follow similar action on Sunday night which saw police carry out 168 raids in towns and cities across the country.
During that operation authorities had made 23 arrests and seized 31 weapons including a rocket launcher.
The raids overnight on Monday took place in Reims, Toulouse and in Strasbourg as well as other cities, with the interior ministry due to release more details later in the day.
They were carried out as part of France's ongoing state of emergency, which has given the police greater powers to take action.
It is believed the raids were not solely linked to Islamic extremism, but also drug and arms trafficking.
Meanwhile the hunt for the Salah Abdeslam - the man considered by French police to be the eighth attacker, goes on.
However on Tuesday morning PM Manuel Valls admitted that the French authorities don't know yet how many people may have been involved in Friday's attacks.
Speaking on France Inter radio Valls said "we still don't have a clear vision of the events, including the number of people involved".
Authorities are also hunting for Abdelhamid Abaaoud, who is now widely considered to be the commander of the attacks in Paris.