The hotel, named Off-Paris Seine, is to be located along the Quai d'Austerlitz, which was until recently the setting for unofficial refugee camp.
It will be located near the Charles de Gaulle bridge, just ten minutes' walk from Notre-Dame Cathedral.
The three star hotel is to house 54 rooms and four suites and, according to those behind it, will be “totally innovative and with no equivalent in Paris.”
It has cost in the region of €11 million to build.
While Paris is home to plenty of floating bars and restaurants and of course welcomes temporary cruise boats with sleeping quarters, there is not currently anything that could be described as a hotel on water.
But the scheme won the support of the Ports de Paris, which had launched a tender looking for new ideas for installations on the Quai d'Austerlitz.
The Paris company Citysurfing and hotel chain Elegancia teamed up to come up with the concept of the floating hotel.
The structure was assembled in Normandy and will be towed down the Seine in the coming weeks. It will welcome its first guests in spring next year.
Rooms at the hotel will cost between €160 and €450 per night.
Guests will have access to a 15 metre-long swimming pool and a 400 square-metre terrace on the bank of the Seine.
The architect promises that guests who are vulnerable to motion sickness will hardly feel the waves from passing boats.
"It is a simple building, designed with two articulated floats crossed by the river. The movement will be insensitive but noticeable, it is akin to rocking," said Gérard Ronzatti.