Luz's famous cover image in January portrayed Muhammad with a sign saying "Je Suis Charlie" under the words "All is forgiven".
"I will no longer draw the figure of Muhammad. It no longer interests me," he told Les Inrockuptibles magazine in an interview published on Wednesday.
"I'm not going to spend my life drawing (cartoons of Muhammad)."
The issue came out a week after the attack by jihadists on the magazine's office left 12 dead. It had a print run of eight million — a record for the French press.
"The terrorists did not win," Luz told Les Inrockuptibles.
"They will have won if the whole of France continues to be scared," he added, accusing the far-right National Front of trying to stir up fear in the wake of the attacks.