The witness raised the alarm with police on Sunday afternoon, claiming to have seen the wild cat near the village of Villeneuve-Loubet.
The call sparked a massive cat-hunt across the area on Sunday afternoon involving police, fire-fighters and officers from the gendarmerie.
On Monday police said they had not yet found any trace of the panther and the National Hunting Office would be taking over the search, France’s TF1 TV reported.
In 2004 a similar hunt was organised around Marseille after the sighting of a panther-like animal. No beast was ever found.