The magazine will give its annual awards in a ceremony at Paris' Ritz hotel on Wednesday evening.
"Jean Dujardin is an actor who makes bold choices," said the magazine.
Other winners of the awards include controversial left-wing politicians Arnaud Montebourg who is named politician of the year.
Montebourg came third in recent elections to choose the Socialist party's presidential candidate, eventually won by François Hollande. He has a glamorous TV presenter girlfriend and is known for his outspoken views.
"Arnaud Montebourg shook up the favourites in the Socialist primaries and has become indispensable to François Hollande," said the magazine.
The actor Hugh Laurie (of "House"), rugby player Vincent Clerc and popular comedian Stéphane Guillon will also receive awards in Wednesday night's ceremony, to be hosted by actor Antoine de Caunes.
"Our winners made their mark on 2011 with one characteristic in common: they were daring," said French GQ editor Anne Boulay.